THERAPY DOSSIER · th-cb6c18639cf4

CCPA (2-chloro-N6-cyclopentyladenosine), a selective A1 adenosine receptor agonist

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02992288 ↗PHASE2completed

Neladenoson Bialanate (Partial A1 Adenosine Receptor Agonist) in Chronic HFrEF

Heart Failure

Enrolment: 427 · Results not recorded

NCT03098979 ↗PHASE2completed

Neladenoson Bialanate (Partial A1 Adenosine Receptor Agonist) in Chronic HFpEF

Heart Failure

Enrolment: 305 · Results not recorded

NCT02040233 ↗PHASE2completed

BAY1067197 Partial Adenosine A1 Receptor Agonist in Chronic Systolic Heart Failure (PARSiFAL-pilot)

Heart Failure

Enrolment: 31 · Results not recorded

NCT00040001 ↗PHASE2completed

A1-Adenosine Receptor Agonist DTI-0009 to Slow Heart Rate in Atrial Fibrillation

Atrial Fibrillation

Enrolment not recorded · Results not recorded

NCT00376454 ↗PHASE2completed

GW493838 (A1 Adenosine Receptor Agonist) in Peripheral Neuropathic Pain

Neuropathic Pain

Enrolment: 113 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22695326 ↗2012Reported benefit

Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia.

MouseIschaemia-reperfusionRenalC57BL/6 wild type, plus sphingosine kinase-1 and sphingosine kinase-2 knockout, S1P1R floxed and PEPCK-Cre transgenic linesMalen = n=3 per sham group; n=4 to 6 per treatment group in the MK5…Intraperitoneal0.1 mg/kg15 min before renal ischaemia

Model: Renal ischemia-reperfusion injury (30 min renal ischaemia, 24 h reperfusion, with right nephrectomy)

CCPA reduced plasma creatinine, tubular necrosis and renal injury score in wild type and sphingosine kinase-2 knockout mice but not in sphingosine kinase-1 knockout mice. Protection was abolished by the S1P1R antagonist W146, by S1P1R siRNA, by proximal tubule specific S1P1R deletion, by ABCC1 inhi…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.

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