THERAPY DOSSIER · th-cab863a3fe5f

Chitosan-immobilised Ficin (plant cysteine protease)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32916198 ↗2020Reported benefit

Anti-biofilm and wound-healing activity of chitosan-immobilized Ficin.

RatWoundtopical application

Model: Staphylococcus aureus-infected skin wound in rats

Infected wound area halved after 4 days with Ficin compared with 6 days in control, and topical immobilised enzyme gave a 3-log reduction in Staphylococcus aureus counts by 6 days versus more than 10 days in control, with smoother reepithelialisation and more native-like collagen structure.

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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