Efficacy and safety of NEM brand eggshell membrane in grade 2/3 knee osteoarthritis: multicentre randomised double-blind placebo-controlled single-crossover study
Osteoarthritis, Knee
Enrolment: 166 · Results not recorded
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Device · Natural biomaterial powder; no ChEMBL entity. Strong device/nutraceutical-level human evidence: the NEM (Natural Eggshell Membrane, ESM Technologies) programme has multiple randomised placebo-controlled trials, plus an independent Spanish RCT.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Osteoarthritis, Knee
Enrolment: 166 · Results not recorded
Osteoarthritis
Enrolment: 67 · Results not recorded
Osteoarthritis
Enrolment: 87 · Results not recorded
Exercise-induced Joint Pain Stiffness and Cartilage Turnover
Enrolment: 60 · Results not recorded
Exercise-induced Joint Pain · Exercise-induced Joint Stiffness · Exercise-induced Joint Cartilage Turnover
Enrolment: 84 · Results not recorded
Exercise-induced Joint Pain · Exercise-induced Joint Stiffness · Exercise-induced Joint Cartilage Turnover
Enrolment: 84 · Results not recorded
Skin Elasticity · Skin Hydration · Skin Barrier to Water Loss · Fingernail Health · Hair Health
Enrolment: 63 · Results not recorded
Skin Sagging · Skin Wrinkling · Skin Dryness
Enrolment: 100 · Results not recorded
Osteoarthritis · Fibromyalgia
Enrolment: 11 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Excisional wound splinting model of the dorsal skin
Processed eggshell membrane powder significantly accelerated wound closure at days 3, 7 and 10, produced significantly thicker granulation tissue at days 10 and 17, and higher collagen deposition at day 10 with limited inflammatory reaction.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.