THERAPY DOSSIER · th-ca25492f8070

Tirilazad (U-74006F)

Drug · Lipid peroxidation inhibitor

Review required. This consequential classification does not yet list attached primary citations.

Evidence & regulatory context

Mechanism: Lipid peroxidation inhibitor
Target: Not recorded
Injury models: TBI · Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Failed in clinical trials
ChEMBL record: CHEMBL1630578 ↗
ChEMBL max phase: Not recorded
Synonyms: Tirilazad; U-74006; U-74006F; Freedox; PNU 74006F
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 3

3 studies reported at therapy level; 3 evidence entries itemised.

PMID 8629252 ↗1996

Tirilazad does not protect rat brain from brachytherapy-induced injury

RatTBI

Extraction: mesh. Machine-extracted fields require source verification.

PMID 8378124 ↗1993

Protection against acute and chronic hyperoxic inhibition of neonatal rat lung development with the 21-aminosteroid drug U74389F

Rat

Extraction: mesh. Machine-extracted fields require source verification.

PMID 8157127 ↗1994

Modeling of acute spinal cord injury in the rat: neuroprotection and enhanced recovery with methylprednisolone, U-74006F and YM-14673

RatSpinal cord injury

Extraction: mesh. Machine-extracted fields require source verification.

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