Circulating histones are mediators of trauma-associated lung injury.
MouseOtherC57BL/6Malen = 52 patients with severe non-thoracic blunt trauma in the cl…
Model: Mouse models of trauma and of histone infusion, alongside a clinical cohort of patients with severe non-thoracic blunt trauma and in vitro endothelial cell studies
Circulating histones surged immediately after severe blunt trauma to levels toxic to cultured endothelial cells and were significantly associated with acute lung injury and SOFA scores. An anti-histone antibody reduced the cytokine, endothelial damage, coagulation and pulmonary histopathological ch…
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