THERAPY DOSSIER · th-c8dd1a65793c

Denuded human amniotic membrane (DHAM); DHAM seeded with bone marrow stromal cells (DHAM-BMSCs)

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03414268 ↗PHASE3completed

Phase 3 RCT of Micronized dHACM Injection vs Saline Placebo in Plantar Fasciitis

Fasciitis, Plantar

Enrolment: 208 · Results not recorded

NCT04990011 ↗NAunknown

Evaluation of Amnion Chorion Membrane in the Repair of Oro Antral Communication

Oroantral Communication

Enrolment: 10 · Results not recorded

NCT06831760 ↗NAcompleted

Type-I Collagen-based Skin Substitute vs Dehydrated Human Amnion/Chorion Membrane in Venous Leg Ulcers

Venous Leg Ulcers

Enrolment: 60 · Results not recorded

NCT06930768 ↗NAnot yet recruiting

Efficacy of NeoThelium FT in the Healing of Venous Leg Ulcers

Venous Leg Ulcer

Enrolment: 132 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22848005 ↗2012Reported benefit

Spinal duraplasty with two novel substitutes restored locomotor function after acute laceration spinal cord injury in rats.

RatSpinal cord injuryHemisection / partialSprague-DawleyFemaleSurgical implantation as dural patch at the lesion site

Model: Acute laceration spinal cord injury with dural tear, repaired by duraplasty

Both duraplasty substitutes restored locomotor function on the BBB scale and re-established neural conduction on motor-evoked potentials by 8 weeks; DHAM-BMSCs reduced total lesion and cystic volumes by nearly 10-fold versus control (p < 0.01), with increased neurotrophic factors and NF-200-positiv…

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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