Creation of an intramedullary cavity by hemorrhagic necrosis removal 24 h after spinal cord contusion in rats for eventual intralesional implantation of restorative materials.
RatSpinal cord injuryContusionLong-EvansFemalen = 166 rats in total; 8 experimental groups of n = 4 for early…Intralesional surgical myelotomy24 hours after contusion
Model: T9 laminectomy followed by NYU weight-drop contusion, 10 g rod dropped from 25 mm (moderate) or 50 mm (severe) onto the exposed dura
The small surgical approach to debridement removed haemorrhagic necrosis without causing swelling, acute inflammation or loss of locomotor recovery and produced a modest improvement in myelination, with the resulting cavity holding 10 to 15 microlitres of hydrogel, whereas medium and extensive myel…
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