Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases.
MouseChemical/toxinBALB/c and C57BL/6Female and malen = 3 to 10 per group depending on experiment (n = 8 for repeat…Intravenous injection2 to 6 micrograms per kilogram intravenously depending on m…2 hours after paracetamol injection in the liver injury model
Model: Cisplatin-induced (20 mg/kg intraperitoneally) and glycerol-induced acute kidney injury, paracetamol-induced acute liver injury (300 mg/kg intraperitoneally) and a skin wound healing model
CuO USNPs gave cytoprotection against reactive oxygen species mediated damage at very low doses and improved outcomes in acute kidney injury, acute liver injury and wound healing, with rapid renal clearance and no necrosis, congestion or haemorrhage in major organs after single or repeated dosing.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.