THERAPY DOSSIER · th-c6bffafad217

Corticotropin-releasing factor (41-residue rat/human sequence)

Hormone

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Burn
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL2108182 ↗
ChEMBL max phase: 3 / 4 (development scale, not regulatory approval)
Synonyms: Corticorelin (human); Corticotropin-releasing factor; Corticotropin-releasing hormone; CRF; Human corticoliberin; NEU-3002; Xerecept
Note: Not recorded

Clinical trials 6

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02736734 ↗PHASE4completed

The Effect of Corticotrophin-releasing Hormone (CRH) on Esophageal Motility in Healthy Volunteers

Esophageal Motility Disorders

Enrolment: 14 · Results not recorded

NCT02674256 ↗PHASE4completed

The Effect of CRH on Esophageal Sensitivity in Healthy Volunteers

Gastrointestinal Hypersensitivity

Enrolment: 15 · Results not recorded

NCT00691522 ↗PHASE2terminated

Open-Label, Imaging Study of Human Corticotropin-Releasing Factor (hCRF) for Reduction of Peritumoral Brain Edema

Peritumoral Brain Edema · Primary Malignant and Metastatic Brain Tumors

Enrolment: 60 · Results not recorded

NCT01459237 ↗EARLY_PHASE1completed

Prospective Evaluation of the Effect of Corticotropin-Releasing Hormone Stimulation on 18F-FDG PET in Cushing's Disease

Pituitary Neoplasm

Enrolment: 30 · Results not recorded

NCT01984177 ↗Phase not recordedcompleted

Effects of Corticorelin Administration on Dopamine Transmission, Craving, and Mood in Cocaine Dependence

Cocaine-Related Disorders · Cocaine Addiction

Enrolment: 17 · Results not recorded

NCT00666068 ↗NAcompleted

Effects of CRH on the Sleep in Patients With Hypopituitarism

Hypopituitarism

Enrolment: 30 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 2785449 ↗1989Reported benefit

Acute inflammatory response of the rat pawskin to acid injury is attenuated by corticotropin-releasing factor.

RatBurnScaldMaleIntravenous28 micrograms/kg10 min before acid immersion

Model: Chemical burn produced by 2 min immersion of the paw in 12 N hydrochloric, 18 N sulfuric or 14 N hydrofluoric acid

Corticotropin-releasing factor given before acid immersion reduced skin weight gain and Evans blue extravasation, indicating attenuation of the acute inflammatory increase in vascular permeability.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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