Uridine as a protector against hypoxia-induced lung injury.
RatOtherWistarMalen = Six rats per group, four groupsIntravenous0.3 mg per 100 g body weight; the mitochondrial ATP-depende…Uridine 30 min before hypoxic exposure; 5-hydroxydecanoate 10 min after uridine…
Model: Acute hypoxic hypoxia produced by 30 min exposure to a gas mixture of 7% oxygen in nitrogen in a sealed 10 L chamber
Hypoxia thickened all layers of the air-blood barrier (epithelial by 61%, interstitial by 47%, endothelial 2.3-fold on arithmetic thickness), raised total mitochondrial number by 88.4% and increased structurally damaged mitochondria sevenfold. Uridine returned epithelial thickness to control values…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.