The antioxidant activities of alkalic-extractable polysaccharides from Coprinus comatus on alcohol-induced liver injury in mice.
MouseChemical/toxinKunmingMalen = Six groups of ten mice in the main experiment; the acute to…Oral, by intragastric administration with a syringe200, 400 and 800 mg/kgPre-treatment for 25 consecutive days before the alcohol challenge on day 26
Model: Acute alcohol-induced liver injury; alcohol 50% v/v at 12 mL/kg intraperitoneally every 12 h for three doses on day 26
ALPS dose-dependently lowered serum AST, ALT and ALP (by 41.5%, 40.6% and 30.9% respectively at 800 mg/kg versus model control), reduced hepatic lipids, CYP2E1, MDA and LPO and inflammatory mediators, raised SOD, GSH-Px, CAT and T-AOC, improved the serum lipid profile and reduced histological liver…
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.