THERAPY DOSSIER · th-c3da76dd8a2e

Glycaemic control (intervention for acute hyperglycaemia)

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00096421 ↗PHASE3completed

Tight Glycemic Control in Patients Hospitalized in a Medical-Surgery Intensive Care Unit: A Randomized Study

Critical Illness · Hyperglycemia · Insulin Resistance

Enrolment: 504 · Results not recorded

NCT06007508 ↗PHASE2terminated

Early Administration of Insulin Glargine in Patients With Diabetic Ketoacidosis

DKA

Enrolment: 8 · Results not recorded

NCT00487162 ↗NAterminated

The Association Between Peri-Operative Hyperglycemia and Major Morbidity and Mortality

Hyperglycemia

Enrolment: 56 · Results not recorded

NCT00764712 ↗NAcompleted

Comparison of Three Protocols for Tight Glycemic Control in Cardiac Surgery Patients

Hyperglycemia

Enrolment: 120 · Results not recorded

NCT00700154 ↗NAterminated

Effect of Insulin Infusion on Metabolic Control and Inflammation in Diabetic Patients During Cardiovascular Intervention or Treatment for Acute Foot Ulcer Infection

Diabetes Mellitus · Hyperglycemia · Infection

Enrolment: 40 · Results not recorded

NCT00501072 ↗NAcompleted

Real Time Continuous Glucose Monitoring System in Type 1 Diabetes Patients on Continuous Intraperitoneal Insulin Infusion

Diabetes Mellitus, Type 1

Enrolment: 12 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27577851 ↗2016Reported benefit

Early care of acute hyperglycemia benefits the outcome of traumatic brain injury in rats.

RatTBIControlled cortical impactSprague-DawleyMaleEarly after injury

Model: Controlled cortical impact traumatic brain injury with strike depths of 3.0 to 4.25 mm at right or left occipitoparietal or frontoparietal regions

Only severe impact (3.5 to 4.25 mm) induced acute hyperglycaemia lasting up to 24 h with reduced insulin sensitivity and secretion for 72 h, and intervention for acute hyperglycaemia lowered the modified neurological severity score from 2 to 7 days after injury.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.

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