Evidence & regulatory context
- Mechanism
- No confident ChEMBL match. Searches for 'hyperoside' returned only CHEMBL559041 (6'-O-acetylhyperoside, an acetylated derivative, no pref_name, max_phase null) and 'quercetin 3-galactoside' returned nothing, so the parent quercetin-3-O-galactoside was not resolvable in this ChEMBL release. FLAGGED: the single ClinicalTrials.gov hit (NCT07678359, ZenRest lotus seed and rice germ extract for sleep quality) does not administer hyperoside as the intervention and was excluded; recorded as zero human trials.
- Target
- Not recorded
- Injury models
- Chemical/toxin
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
MouseChemical/toxinOral
Model: Acetaminophen (N-acetyl-para-aminophenol) induced acute hepatic injury in mice, with parallel in vitro LO2 hepatocyte injury
Hyperoside dose-dependently reduced markers of acetaminophen-induced hepatic injury and oxidative stress, with the protective effect dependent on Nrf2.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
