THERAPY DOSSIER · th-c1335b96b3e2

Dynamic Stimulation, epidural electrical spinal stimulation

Device · Epidural electrical spinal-cord stimulation (Dynamic Stimulation); neuromodulation device.

Evidence & regulatory context

Mechanism: Epidural electrical spinal-cord stimulation (Dynamic Stimulation); neuromodulation device.
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04052776 ↗Injury indicationPHASE1completed

Pharmacological Neuromodulation on Leg Motor Activity in SCI With Epidural Electrical Stimulation

Spinal Cord Injuries

Enrolment: 3 · Results not recorded

NCT04883463 ↗Injury indicationNArecruiting

Neuromodulation (Epidural Stimulation) to Improve Respiratory Function in Cervical SCI

Spinal Cord Injuries

Enrolment: 12 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32057795 ↗2020Reported benefit

Acute neuromodulation restores spinally-induced motor responses after severe spinal cord injury.

RatSpinal cord injuryContusionSprague-DawleyFemaleEpidural stimulation applied to four lumbosacral segments via a multi-electrode arrayAcutely after the contusive injury

Model: Calibrated contusive spinal cord injury at lumbar level

Repetitive Dynamic Stimulation restored spinally-evoked motor EMG responses that had been suppressed by the calibrated spinal cord contusion, whereas sham experiments showed no spontaneous recovery.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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