THERAPY DOSSIER · th-bfc1c240c6a5

Vitis thunbergii ethanol extract (EVT)

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22698911 ↗2012Reported benefit

Hepatoprotective effect of the ethanol extract of Vitis thunbergii on carbon tetrachloride-induced acute hepatotoxicity in rats through anti-oxidative activities.

RatChemical/toxinSprague-DawleyMaleOral administration

Model: Carbon tetrachloride (CCl4) induced acute hepatotoxicity

Oral EVT significantly decreased ALT and AST, reduced hepatic oxidative stress and increased catalase, superoxide dismutase, glutathione peroxidase and glutathione. Serum TNF-alpha, IL-1beta and nitric oxide fell, iNOS and COX-2 expression was blocked, and fatty degeneration, cytoplasmic vacuolisat…

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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