THERAPY DOSSIER · th-bfa501fed09b

Copaiba oil (Copaifera reticulata), composition 45% beta-caryophyllene

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 9

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04127279 ↗PHASE4completed

Stress Relief Properties of a Cosmetic Routine: Psychobiological Evidence

Stress Physiology · Stress, Psychological

Enrolment: 40 · Results not recorded

NCT06708702 ↗PHASE2withdrawn

Phase II Study of Copaiba-based Mouthwash in Oral Mucositis Prevention and Treatment During Radiotherapy

Oral Mucositis · Oral Mucositis (Ulcerative) Due to Radiation

Enrolment: 0 · Results not recorded

NCT05308732 ↗PHASE1active not recruiting

Phase I Study of Multiple Ascending Dose of Copaiba in Oral Cancer Patients Submitted to Radiotherapy

Head and Neck Neoplasms · Mucositis Oral · Radiotherapy; Complications

Enrolment: 20 · Results not recorded

NCT06872749 ↗NAcompleted

Effect of Experimental Gel Containing Copaiba Oil-resin in Control of Dentin Hypersensitivity

Pain · Dentin Sensitivity · Dentin Desensitizing Agents

Enrolment: 75 · Results not recorded

NCT07767669 ↗NAcompleted

Controlled Study of a Topical Cream (Saje Pain Release Joint & Arthritis Cream) on Arthritis, Joint, and Muscle Pain

Arthritis · Joint Pain · Muscle Pain · Musculoskeletal Pain · Joint Stiffness

Enrolment: 80 · Results not recorded

NCT05021146 ↗NAunknown

Essential Copaiba Oil for Chronic Low Back Pain

Chronic Low-back Pain

Enrolment: 300 · Results not recorded

NCT06066671 ↗NAcompleted

Experimental Gel Based on Copaiba Oil Resin in Reducing Post-bleaching Tooth Sensitivity

Tooth Bleaching Pain

Enrolment: 75 · Results not recorded

NCT06931977 ↗NAcompleted

Wellness and Epigenetic Impact of a Natural Product Supplement System With Copaiba Softgels

Healthy

Enrolment: 97 · Results not recorded

NCT05873933 ↗NAwithdrawn

Multi-Function Skincare Product (Hemptress Oil) to Improve Aging, Eczema, and Acne Outcomes

Acne · Eczema · Skin Aging

Enrolment: 0 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29039895 ↗2018Mixed findings

Effects of Copaiba oil in the healing process of urinary bladder in rats.

RatWoundWistarmalen = 10 rats, 5 per groupTopical, injected directly onto the bladder suture line0.63 mL/kg per the abstract; the methods section of the ful…Immediately after closure of the cystotomy

Model: Laparotomy with 1 cm cystotomy of the urinary bladder closed with 4-0 polydioxanone suture

Adhesion formation did not differ between groups (p=0.1481). Copaiba oil significantly increased foreign-body giant cell reaction and vascular proliferation (both p=0.047) but did not alter acute inflammation, necrosis, fibroblast number, collagen grade or re-epithelialisation. Collagen volumetric…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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