Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Ischaemia-reperfusion
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 8
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Use of Cytal Wound Matrix and MicroMatrix for the Management of Wounds
Wounds
Enrolment: 37 · Results not recorded
A Randomized Clinical Investigation to Evaluate the Efficacy of Cytal Burn Matrix in the Management of Partial-Thickness Burns to the Hand
Partial Thickness Burn of Hand
Enrolment: 0 · Results not recorded
A Phase I, Open-label Study of the Effects of Percutaneous Administration of an Extracellular Matrix Hydrogel, VentriGel, Following Myocardial Infarction
Myocardial Infarction · Heart Failure · Left Ventricular Remodeling
Enrolment: 15 · Results not recorded
A Prospective, Randomized, Controlled, Longitudinal Study Using a Porcine Urinary Bladder-Derived Extracellular Matrix (MatriStem) in the Management of Diabetic Foot Ulcers
Neuropathic Diabetic Foot Ulcer
Enrolment: 17 · Results not recorded
Randomized Controlled Platform Trial Assessing Cellular, Acellular and Matrix-like Products (including Urinary Bladder Matrix sheet) in Hard-to-Heal Diabetic Foot and Venous Leg Ulcers
Diabetic Foot Ulcer · Venous Leg Ulcer
Enrolment: 350 · Results not recorded
A Randomized Clinical Trial Comparing Concomitant Use of MicroMatrix With Cytal Wound Matrix 2-Layer to Standard of Care in Patients With Stage 3 or 4 Pressure Injuries
Pressure Ulcer, Stage III · Pressure Ulcer, Stage IV
Enrolment: 60 · Results not recorded
A Prospective, Randomized, Controlled Trial Comparing Cytal Wound Matrix 1-Layer to Standard of Care in the Management of Diabetic Foot Ulcers
Diabetic Foot · Diabetes Mellitus
Enrolment: 15 · Results not recorded
The Management of Pilonidal Wounds With ACell MicroMatrix and Cytal Wound Matrix: A Case Series (Powder Urinary Bladder Matrix)
Pilonidal Disease
Enrolment: 2 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMalen = 56 rats with lesion volume greater than 40 mm3 randomly ass…Intracerebral injection into the stroke lesion cavity using an injection-drainage approach with a 250 uL Hamilton syringe and a 24 G drainage cannula, delivered by frame-mounted injection pump0, 3, 4 and 8 mg/mL protein concentrations; lesion-equivale…14 days after middle cerebral artery occlusion
Model: Transient intraluminal right middle cerebral artery occlusion for 70 minutes followed by reperfusion, with hydrogel implanted into the resulting 14-day-old stroke cavity
Less concentrated hydrogels (3 and 4 mg/mL) degraded by about 95% at 90 days with progressive macrophage infiltration, robust endothelial invasion with neovascularisation, and neural progenitor differentiation into mature neurons plus oligodendrocyte invasion; the stiffer 8 mg/mL hydrogel resorbed…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
