Acute toxicity and gastroprotection studies with a newly synthesized steroid.
MixedChemical/toxinRat strain not stated in the retrieved text; mice were ICRMale rats; 18 male and 18 female mice in the toxicity studyn = 48 rats in 8 groups of 6; 36 mice in 3 groups of 12 for the…Oral1, 5, 10, 15 and 20 mg/kg in 10 per cent Tween 20 at 5 mL/k…Pre-treatment one hour before ethanol
Model: Ethanol-induced gastric mucosal injury, absolute ethanol 5 mL/kg by oral gavage after a 24 hour fast, with euthanasia one hour later
AMDCP dose-dependently reduced ethanol-induced gastric lesion area, with 10 mg/kg comparable to omeprazole 20 mg/kg, and increased mucus, gastric pH and prostaglandin E2 while lowering malondialdehyde, with no toxicity up to 2000 mg/kg.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.