Prevention and mitigation of acute radiation syndrome in mice by synthetic lipopeptide agonists of Toll-like receptor 2 (TLR2).
Model: Bilateral total body gamma irradiation with caesium-137. High dose rate 2.3 Gy/min or 1.55 Gy/min, doses 4 Gy sub-lethal and 7 to 13 Gy for survival curves, 10 Gy LD100 in ICR and 9 Gy LD100 in C57BL/6J; low dose rate arm 0.41 plus or minus 0.05 cGy/min for 60 or 70 h giving 14.4 or 16.8 Gy; chimera conditioning 2 x 6 Gy 24 h apart
A single subcutaneous dose of synthetic lipopeptide given between 48 h before and 24 h after total body irradiation increased 30-day survival, raising LD50 from 8.5 to 11.25 Gy with a dose reduction factor of 1.32 for prophylaxis and 1.09 for mitigation. Protection required TLR2 and was largely ini…
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