THERAPY DOSSIER · th-bb0ef75a59cb

Human HC016 cells, expanded human adipose mesenchymal stem cells pulsed with hydrogen peroxide

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02917291 ↗Injury indicationPHASE1/PHASE2unknown

Phase 1/2 of FAB117-HC (HC016 allogeneic adipose MSC pulsed with H2O2) in Acute Traumatic SCI

Acute Traumatic Spinal Cord Injury

Enrolment: 48 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31821721 ↗2019Reported benefit

Efficacy of human HC016 cell transplants on neuroprotection and functional recovery in a rat model of acute spinal cord injury.

RatSpinal cord injuryContusionWistarmaleCell graft to the injured cord48 hours after injury

Model: Contusion model of acute spinal cord injury in rats

HC016 cells showed superior survival to unpulsed adipose mesenchymal stem cells and produced statistically significant locomotor recovery with long-term neuroprotection, greater axonal regeneration and reduced glial reactivity.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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