THERAPY DOSSIER · th-b822c4536bf5

Human umbilical cord blood mesenchymal stem cells (hUCB-MSCs)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02812121 ↗PHASE2unknown

Umbilical Cord Blood Derived Mesenchymal Stem Cells Infusion for HBV-Related Acute-on-Chronic Liver Failure: A Randomized Controlled Trial

Liver Failure

Enrolment: 261 · Results not recorded

NCT06598202 ↗PHASE1/PHASE2recruiting

An Exploratory Study on the Use of Intranasal Administration of Small Extracellular Vesicles for the Treatment of Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis

Enrolment: 38 · Results not recorded

NCT05345418 ↗PHASE1/PHASE2unknown

Evaluation of the Safety and Efficacy of Umbilical Cord-Derived Mesenchymal Stem Cell (VCELL 1) for Male Patients With Sexual Deficiency: A Phase I/IIa Randomised Crossover Trial

Sexual Dysfunction Male

Enrolment: 158 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23933426 ↗2013Mixed findings

The anti-apoptotic and neuro-protective effects of human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) on acute optic nerve injury is transient.

RatOtherSprague-DawleyIntravitreal transplantationAfter injury

Model: Acute optic nerve injury

hUCB-MSCs transiently reduced apoptosis and promoted RGC survival early but did not prevent eventual RGC death.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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