Prostaglandin F2alpha FP receptor antagonist improves outcomes after experimental traumatic brain injury
MouseTBIControlled cortical impactC57BL/6, wildtype and FP receptor knockoutMalen = 83 male wildtype and 20 male FP receptor knockout mice in t…Intraperitoneal1 and 10 mg/kg, dissolved in dimethyl sulfoxide at 25 mg/mL…Post-injury, within ten minutes of controlled cortical impact
Model: Controlled cortical impact through a 4 mm right parietal craniotomy, impact tip 3 mm, velocity 3 m/s, compression time 100 ms, depth 1 mm; sham animals underwent craniotomy only
Controlled cortical impact produced cortical lesions of 20.0 +/- 1.0 mm3 and hippocampal swelling of 146.5 +/- 7.4 percent of contralateral. AL-8810 had no effect on cortical lesion volume at either dose but reduced hippocampal swelling to levels not different from sham, significant versus saline o…
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