Thermotolerance does not reduce the size or remodeling of radiofrequency lesions in the rat myocardium.
RatOtherWistarMalen = 44 rats, 22 per group; n = 10 per group at 2 h and n = 12 p…Whole body heat stressInternal temperature 42 degrees C for 10 min48 h before ablation, with additional intervals of 3, 12, 24 and 72 h tested
Model: Unipolar radiofrequency ablation lesion of the left ventricular free wall, 12 W for 10 s with a 4.5 mm tip catheter
Acute lesions were 27 +/- 2 versus 27 +/- 3 mm2 and chronic lesions 17 +/- 1 versus 19 +/- 1 mm2, with no histological or echocardiographic difference.
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