THERAPY DOSSIER · th-b54acc8c6dee

Light-emitting diode photobiomodulation (630 plus or minus 20 nm, 300 mW continuous wave)

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04424823 ↗NAunknown

Light-Emitting Diode Photobiomodulation Therapy for Non-specific Low Back Pain in Working Nurses: A Single-center, Double-blind, Prospective, Randomized Controlled Trial

Lower Back Pain

Enrolment: 148 · Results not recorded

NCT06046118 ↗NArecruiting

Outcomes of Photobiomodulation in DRy Age Related macUlar Degeneration: a proSpective multicEnter raNdomized Controlled (DRUSEN) Study

Age-Related Macular Degeneration

Enrolment: 180 · Results not recorded

NCT04044989 ↗NAcompleted

Placebo-Controlled, Randomized, Double Blind Trial of Effect of Photobiomodulation Therapies On The Root Resorption Associated With Orthodontic Forces: A Pilot Study Using Micro Computed Tomography

Orthodontic Pathological Resorption of External Root · Orthodontic Tooth Movement

Enrolment: 30 · Results not recorded

NCT03724552 ↗NAcompleted

Evaluation of LED Therapeutic Effect in Youth and Adults With Autism Spectrum Disorder: An Open-Label Pilot Study of a Novel Approach

Autism · Autism Spectrum Disorder

Enrolment: 12 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 33037560 ↗2020Reported benefit

Photobiomodulation therapy on expression of HSP70 protein and tissue repair in experimental acute Achilles tendinitis.

RatChemical/toxinWistarMalen = 30 rats in total: control n = 8, tendinitis n = 11, LED n =…Transcutaneous irradiation in contact with the skin over the tendon, spot size 1 cm9 J per point (9 J/cm2) delivered over 30 s at one point ov…First irradiation 1 h after collagenase injury

Model: Acute Achilles tendinitis induced by peritendinous injection of collagenase (100 microlitres)

Photobiomodulation increased mean HSP70 HSCORE, fibroblast number and collagen content relative to untreated tendinitis and control groups (P less than or equal to 0.05).

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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