Essential amino acid enriched high-protein enteral nutrition modulates insulin-like growth factor-1 system function in a rat model of trauma-hemorrhagic shock.
RatHaemorrhage/shockUnspecifiedSprague-Dawleymalen = n=90 rats in 5 groups; 6 animals per group harvested on eac…Enteral (via gastrostomy catheter)Commenced after trauma-haemorrhagic shock, with sampling on days 2, 4 and 6
Model: Trauma-haemorrhagic shock with midline laparotomy and gastrostomy catheter placement under ketamine anaesthesia (100 mg/kg body weight intraperitoneally)
Trauma-haemorrhagic shock significantly reduced muscle mass and produced marked derangement of the IGF-1 and IGF binding protein axis with impaired mTOR signalling. Nutrition support maintained muscle mass, most effectively with the essential amino acid-enriched high-protein formulation, which gave…
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