THERAPY DOSSIER · th-b406f5aba7a6

Raphia hookeri ethanolic pulp extract (RHEE)

Nutraceutical · Crude ethanolic fruit-pulp extract of Raphia hookeri (African raffia palm); no ChEMBL entity for a multi-component botanical extract. No ClinicalTrials.gov record (searched, not assumed).

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Crude ethanolic fruit-pulp extract of Raphia hookeri (African raffia palm); no ChEMBL entity for a multi-component botanical extract. No ClinicalTrials.gov record (searched, not assumed).
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31449279 ↗2019Reported benefit

Raffia hookeri Ethanolic Pulp Extract Ameliorated Neuronal Damage and Brain Oxidative Stress Following Mechanical-Induced Traumatic Brain Injury in Rats.

RatTBIWeight-drop / impact-accelerationWistarFemalen = 36 rats in 6 groups of 6Oral gavage100 mg/kgStarted after injury on experimental day 1

Model: Sharp and blunt traumatic brain injury induced by a modified weight-drop technique

Both injury types raised malondialdehyde and reduced glutathione, superoxide dismutase and catalase. Extract administration reduced oxidative damage and lessened subarachnoid and parenchymal haemorrhage in both sharp and blunt injury groups.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

Loading the evidence…