Low molecular-weight gel fraction of Aloe vera exhibits gastroprotection by inducing matrix metalloproteinase-9 inhibitory activity in alcohol-induced acute gastric lesion tissues.
MouseChemical/toxinBALB/cMalen = 28 mice in total, 7 mice per group across four groupsOral (p.o.)150 mg/kg body weight30 min before alcohol administration (pre-treatment)
Model: Alcohol-induced acute gastric lesion; mice fasted 24 h then given absolute alcohol 8 mL/kg orally, with 1 h exposure before euthanasia
lgfAv-treated mice showed markedly fewer gastric ulcer lesions than alcohol-only controls, and the transcriptional and protein expression of MMP-9 was substantially reduced, indicating gastroprotection mediated in part by MMP-9 suppression.
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