THERAPY DOSSIER · th-b358a85e900e

Silk fibroin film delivering necrostatin-1

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05191082 ↗Injury indicationNAunknown

Silk fibroin membranes, loaded or not with neurotensin, on open palatal wounds

Wound Healing · Palate Wound

Enrolment: 66 · Results not recorded

NCT05171400 ↗Injury indicationNAunknown

Silk fibroin film loaded or not with insulin on palatal mucosa wound healing

Wound Healing · Palate Wound

Enrolment: 75 · Results not recorded

NCT06050863 ↗PHASE1unknown

Subgingival chlorhexidine, silk fibroin and combination as local drug delivery in periodontitis

Periodontal Pocket

Enrolment: 15 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30836199 ↗2019Reported benefit

Film interface for drug testing for delivery to cells in culture and in the brain.

MouseTBIControlled cortical impactC57BL/6 (reported as CL7/BL6 in the retrieved text)n = Necrostatin-1 n = 5 per group; other assays n = 3 to 15silk film placed on the exposed cortical surface within the burr hole, bone flap replaced2 ug (8 nmol) of necrostatin-1 per 4 mm filmfilms implanted 24 h before injury; assessment at 5 h post-injury

Model: Controlled cortical impact over the left parietotemporal cortex, 3 mm flat-tip impounder, 6 m/s, 0.3 mm depth

Film-delivered necrostatin-1 reduced necrotic cell counts by about 40 percent compared with vehicle films (96 +/- 8 versus 164 +/- 8 cells per 200x field), and silk films were well tolerated in brain.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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