THERAPY DOSSIER · th-b29c004eaa61

Blue light phototherapy at 415 plus or minus 10 nm

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05739058 ↗Injury indicationNAcompleted

Violet-Blue Light Inactivation of Bacteria in Chronic Wounds (FlashHeal)

Wound Infection · Wound Heal · Photobiology

Enrolment: 22 · Results not recorded

NCT07042659 ↗Injury indicationNAcompleted

Accelerated Photobiomodulation Protocol With Blue Light in Hard-to-heal Wounds

Hard-to-heal Wounds · Chronic Wounds

Enrolment: 11 · Results not recorded

NCT04300010 ↗PHASE4completed

Efficacy of Blue Light Therapy in Reducing Cutibacterium Acnes Bioburden at the Deltopectoral Interval

Acne

Enrolment: 60 · Results not recorded

NCT01689935 ↗PHASE1completed

Pilot Trial to Reduce Side-Effects of Photodynamic Therapy for Moderate to Severe Acne (blue light arm)

Acne Vulgaris

Enrolment: 35 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23406384 ↗2013Reported benefit

Blue light eliminates community-acquired methicillin-resistant Staphylococcus aureus in infected mouse skin abrasions.

MouseWoundBALB/cFemaleTopical illumination of the infected abrasion41.4 J/cm2 on day 0 and 108 J/cm2 on day 1 in vivo; 170 J/c…30 min after bacterial inoculation for acute infection and 24 h after inoculati…

Model: Skin abrasion inoculated with bioluminescent community-acquired MRSA strain USA300LAC::lux

Blue light produced more than a 2-log10 reduction in bacterial luminescence in mouse skin abrasions in both acute and established infections while sparing keratinocytes, although bacterial regrowth occurred by 24 h after therapy.

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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