THERAPY DOSSIER · th-b27aa22d2cb5

Lentiviral vector-delivered shRNA targeting Nav1.7 (LV3-SCN9AsiRNA-GFP)

Other

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Burn
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27514860 ↗2016Reported benefit

shRNA mediated knockdown of Nav1.7 in rat dorsal root ganglion attenuates pain following burn injury.

RatBurnContact / flameSprague-DawleyMalen = 68 adult male Sprague-Dawley rats across four groups; 16 pe…Dorsal root ganglion microinjection (L4, described as L5 in the conclusions)4 microlitres of vector; titre not statedDay zero, the same day as the burn injury

Model: Focal second-degree contact burn, hind paw held for 15 seconds on a metal plate heated by circulating water at 85 degrees Celsius under isoflurane anaesthesia

Burn injury lowered mechanical and heat withdrawal thresholds for 14 to 21 days and increased dorsal root ganglion Nav1.7 and c-fos at day 7. Nav1.7 shRNA delivered on day zero attenuated mechanical allodynia from day 3 (p = 0.0008) and thermal hyperalgesia from day 7 (p < 0.0001), reduced dorsal r…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.

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