Isoliquiritigenin protects against sepsis-induced lung and liver injury by reducing inflammatory responses.
MouseEndotoxin/LPSC57BL/6Male (MeSH indexed)Pretreatment before lipopolysaccharide challenge
Model: Lipopolysaccharide-induced acute lung injury and sepsis-induced lung and liver injury, with mouse primary peritoneal macrophages exposed to lipopolysaccharide in vitro
Isoliquiritigenin pretreatment reduced inflammatory cytokine expression in vitro and prevented lipopolysaccharide-induced structural lung damage and inflammatory infiltration, attenuating sepsis-induced lung and liver injury through inhibition of nuclear factor kappa B signalling
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