Radioprotective Effect of Walnut Oligopeptides Against Gamma Radiation-Induced Splenocyte Apoptosis and Intestinal Injury in Mice.
MouseRadiationBALB/cFemalen = Six groups of 30 mice, each split into three subgroups of 10Oral, in drinking water0.22, 0.44 and 0.88 g/kg body weight14 days before irradiation and continued afterwards
Model: Single whole body cobalt-60 gamma irradiation at 8 Gy for the survival subgroup and 3.5 Gy for the other subgroups, both at 1 Gy/min, delivered on the fifteenth day of dosing
Walnut oligopeptides prolonged survival after 8 Gy, accelerated weight and organ index recovery, raised white cell counts and antioxidant enzymes, lowered TNF-alpha and gut permeability markers, and limited splenocyte apoptosis and mucosal injury.
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