THERAPY DOSSIER · th-b078fd6c0812

Hyperbaric oxygen therapy; ozone therapy

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

4 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03101982 ↗Injury indicationPHASE2terminated

Hyperbaric Oxygenation (HBO) in Traumatic Spinal Cord Injury (EOS) - Pilot Study

Traumatic Injury of the Spinal Cord

Enrolment: 11 · Results not recorded

NCT07214415 ↗Injury indicationPHASE2recruiting

Evaluating the Effects of Hyperbaric Oxygen Therapy on Cognitive Function, Mental Health, and Quality of Life in Veterans

TBI Traumatic Brain Injury · PTSD · Post Concussive Syndrome

Enrolment: 54 · Results not recorded

NCT03674749 ↗Injury indicationNAunknown

Effect of Meditation and Hyperbaric Oxygen Therapy on Cognition, Healing Process and Overall Well-being in Elderly Patients With Chronic Wounds

Wound

Enrolment: 50 · Results not recorded

NCT02483650 ↗Injury indicationPhase not recordedunknown

The Registry of Hyperbaric Oxygen Therapy Treated Patients

Crush Injury, Compartment Syndrome & Other Acute Traumatic Ischemias · Compromised Grafts and Flaps · Acute Thermal Burn Injury · Delayed Radiation Injury

Enrolment: 5000 · Results not recorded

NCT02452619 ↗Phase not recordedunknown

Brain Angiogenesis Induced by Hyperbaric Oxygen Therapy Visualized by Perfusion MRI in Brain Injury Patients

Hyperbaric Oxygen Therapy · Mild Cognitive Impairment

Enrolment: 30 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24936837 ↗2014Reported benefit

Effectiveness of hyperbaric oxygen and ozone applications in tissue healing in generated soft tissue trauma model in rats: an experimental study.

RatOtherSprague-Dawleymalen = 63 adult male Sprague-Dawley rats divided into three groups

Model: Experimentally generated soft tissue trauma, described as a form of acute traumatic ischaemia; hindlimb soft tissue trauma

Both hyperbaric oxygen and ozone groups showed statistically significant reductions in inducible nitric oxide synthase and lipid peroxidation levels compared with controls. Inflammation was significantly reduced in both treatment groups relative to control, and oedema decreased significantly in all…

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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