THERAPY DOSSIER · th-b02b70492ba3

Human foetal spinal cord-derived neural precursor cells transplanted as neurospheres

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04812431 ↗Injury indicationPHASE1/PHASE2recruiting

Phase 1/2a study of PSA-NCAM(+) neural precursor cells derived from hESC line in sub-acute AIS-A spinal cord injury

Spinal Cord Injury, Acute · Spinal Cord Injury at C4 Level With Complete Lesion · Spinal Cord Injury at C5-C7 Level With Complete Lesion

Enrolment: 5 · Results not recorded

NCT01772810 ↗Injury indicationPHASE1unknown

Phase 1 safety study of human spinal cord-derived neural stem cell transplantation for chronic SCI

Spinal Cord Injury (SCI)

Enrolment: 8 · Results not recorded

NCT01730716 ↗PHASE2unknown

Phase II, open-label dose escalation and safety study of human spinal cord derived neural stem cell transplantation for ALS

Amyotrophic Lateral Sclerosis

Enrolment: 18 · Results not recorded

NCT01348451 ↗PHASE1unknown

Phase I, first in human, feasibility and safety study of human spinal cord derived neural stem cell transplantation for ALS

Amyotrophic Lateral Sclerosis

Enrolment: 18 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24412492 ↗2014Mixed findings

Neuroprotective effects of human spinal cord-derived neural precursor cells after transplantation to the injured spinal cord.

RatSpinal cord injuryContusionFemaleTransplantation into the injured spinal cord9 days after contusion; immediately, 1 week or 7 weeks after compression

Model: Spinal contusion injury and spinal compression injury

Transplantation 9 days after contusion enhanced hindlimb recovery. After compression injury, transplantation immediately or at 1 week significantly improved recovery but transplantation at 7 weeks did not. No allodynia and no focal tumour growth were seen. Host neuron survival was highest in the ac…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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