THERAPY DOSSIER · th-af0a09d799fc

Bifunctional opioid agonist / NK1 receptor antagonist hybrid peptides (SBCHM1, RCCHM3, RCCHM6; hybrids RCCHM1 to 8 synthesised), with opioid parents AN81 and KGOP1 as references

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28699350 ↗2017Mixed findings

Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice.

MouseOtherAlbino Swiss CD-1 IGS (Charles River)MaleIntrathecal, 5 microlitres by lumbar puncture between L5 and L6 in non-anaesthetised mice using a 30 gauge needle on a 25 microlitre Hamilton syringeRotaRod screening at 1 microgram in 5 microlitres per anima…Single administration during the established neuropathic phase; behavioural exp…

Model: Chronic constriction injury of the sciatic nerve after Bennett and Xie: three 4/0 silk ligatures placed around the nerve distal to the sciatic notch at 1 mm spacing under isoflurane anaesthesia

In naive mice the pure opioid parents gave near 100 per cent maximum possible effect on tail-flick whereas hybrids reached only about 60 to 70 per cent. Under neuropathic conditions the opioid parents largely lost efficacy while the best hybrid produced close to 100 per cent maximum possible effect…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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