THERAPY DOSSIER · th-ad5670689744

Noncontact low-frequency phased-array ultrasound

Device · Noncontact low-frequency phased-array ultrasound; wound-therapy device.

Evidence & regulatory context

Mechanism: Noncontact low-frequency phased-array ultrasound; wound-therapy device.
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31985636 ↗2020Reported benefit

Noncontact Phased-Array Ultrasound Facilitates Acute Wound Healing in Mice.

MouseWoundC57BL/6JMalen = 102 mice in total; 5 to 6 wounds per time point for histolo…Noncontact transcutaneous airborne ultrasound40 kHz ultrasound at 5.1 W/cm2, 10 Hz pulse frequency, outp…Started immediately after wounding

Model: Bilateral 6 mm full-thickness excisional dorsal skin wounds, silicone-stented to heal by secondary intention

Treated wounds epithelialised faster than sham wounds on day 5 (65 +/- 27 per cent versus 30 +/- 33 per cent closure) and day 7 (95 +/- 4 versus 81 +/- 9 per cent), showed greater CD31 area on day 2 (4.6 +/- 1.7 versus 2.2 +/- 1.0 per cent) and greater collagen density on day 5 (44 +/- 14 versus 28…

Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.

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