THERAPY DOSSIER · th-ab8057eb0942

Fibrin perihepatic packing (fibrin dressing)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28246619 ↗2017Reported benefit

Effect of Fibrin Packing on Managing Hepatic Hemorrhage and Liver Wound Healing in a Model of Liver Stab Wound in Rat.

RatWoundSprague DawleyMalen = 20 adult male rats in two groupsTopical perihepatic packingApplied at the time of the stab wound during surgery

Model: Liver stab wound created with a number 15 scalpel cutting bilateral liver capsules and liver tissue, producing acute bleeding

Estimated blood loss was 2.89 plus or minus 0.73 mL with fibrin packing versus 4.98 plus or minus 0.77 mL with gauze packing (p < 0.001). Mortality was 0% versus 50% within 12 h. ALT and AST returned to normal in 4 days versus 6 days and haematocrit recovered by 48 h versus 72 h. Total serum biliru…

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

Loading the evidence…