Blocking junctional adhesion molecule C promotes the recovery of cisplatin-induced acute kidney injury
MouseChemical/toxinC57BL/6MaleIntraperitoneal1.5 mg/kg per injectionFirst dose delayed until day 4 after cisplatin, at the peak of renal injury
Model: Cisplatin-induced acute kidney injury, single intraperitoneal injection of cisplatin at 18 mg/kg (2 mg/ml in normal saline)
Antibody treatment during the recovery phase significantly increased circulating reverse-transmigrated neutrophils on day 5, significantly reduced kidney neutrophil infiltration and renal IL-6 expression, and accelerated the fall in blood urea nitrogen and creatinine on days 5 and 6 with a lower tu…
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