THERAPY DOSSIER · th-aa235a31a212

Previously frozen, irradiated porcine skin graft (biologic dressing)

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

5 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06223269 ↗Injury indicationPHASE3recruiting

Phase III Trial of realSKIN (Skin Xenotransplant) for Complete Wound Closure of Mixed-Depth Full-Thickness Burns

Burns · Thermal Burn

Enrolment: 50 · Results not recorded

NCT03695939 ↗Injury indicationPHASE1/PHASE2completed

Phase 1/2 Study of realSKIN (Skin Xenotransplant) for Closure of Deep-Partial and Full-Thickness Burn Wounds

Deep Full-thickness Burn Injury

Enrolment: 25 · Results not recorded

NCT04410497 ↗Injury indicationNAcompleted

Silver Foam Dressing Superior to Porcine Xenograft in Pediatric Scalds

Burns Scald

Enrolment: 58 · Results not recorded

NCT03931746 ↗Injury indicationNAterminated

Porcine Xenograft Versus Second Intention Healing After Dermatologic Surgery

Wound Healing and Scar Quality

Enrolment: 14 · Results not recorded

NCT06170008 ↗Injury indicationNAnot yet recruiting

Efficacy of a Transparent Silicone Membrane for Second-degree Burn and Skin Graft Wounds (decellularised pig skin comparator)

Second-degree Burn Wounds · Skin Graft Wounds

Enrolment: 40 · Results not recorded

NCT04490213 ↗Phase not recordedcompleted

Scarring at Donor Sites After Split-Thickness Skin Graft (Mediskin porcine dressing arm)

Donor Site Complication

Enrolment: 17 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 6358453 ↗1983Outcome unclear

The healing of hamster oral mucosal wounds covered by porcine grafts. A histologic study.

HamsterWoundMalen = 20 hamstersSutured onto the recipient bed5 mm square graftAt the time of wounding

Model: Split-thickness 5 mm square excisional wound prepared in the cheek pouch

At 3 days the graft showed necrosis with host epithelium migrating beneath it and some acute inflammation. By 7 days all 7 grafts had sloughed and epithelialisation was complete, with the graft bed showing maturing collagenous tissue and a mild chronic inflammatory infiltrate. Healing was almost co…

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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