Collagen scaffold combined with human umbilical cord-mesenchymal stem cells transplantation for acute complete spinal cord injury.
RatSpinal cord injuryComplete transectionSprague-Dawley rats (specific-pathogen-free); beagle caninesFemalen = Rats n = 40 randomised to 4 groups of 10; canines n = 20 ra…Surgical implantation of the cell-laden collagen scaffold into the transected spinal cord gapRats: hUC-MSC-laden 4 mm diameter collagen scaffold; canine…Immediately after the spinal cord injury, during the same transection surgery
Model: Complete spinal cord transection by microsurgery. Rats: laminectomy T9-T11, 1.5 mm section of cord removed at T10. Canines: laminectomy T8-T11, 3 mm section of cord completely transected
In rats, BBB scores in the scaffold plus hUC-MSC group were significantly higher than the injury and scaffold-alone groups at 4, 6 and 8 weeks, Rivlin inclination angles were higher than the scaffold-alone group at 3, 4, 6 and 8 weeks, and motor evoked potential amplitude was enhanced with shortene…
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