THERAPY DOSSIER · th-a7f87b3ec7d7

Bone marrow stromal cell conditioned medium combined with methylprednisolone

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 3

1 studies reported at therapy level; 3 evidence entries itemised.

PMID 30686001 ↗2018Reported benefit

Evaluation of the effect of BMSCs condition media and methylprednisolone in TGF-beta expression and functional recovery after an acute spinal cord injury.

RatSpinal cord injuryUnspecifiedWistarIntraperitonealAfter acute spinal cord injury

Model: Acute spinal cord injury in adult Wistar rats

Combined methylprednisolone and conditioned medium produced significantly better functional recovery, reduced TGF-beta1 expression, smaller cavity size and greater mean spinal cord volume than the other groups.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

PMID 20307513 ↗2010

Bone marrow stromal cell transplantation for treatment of sub-acute spinal cord injury in the rat

RatSpinal cord injury

Extraction: mesh. Machine-extracted fields require source verification.

PMID 19645530 ↗2009

Bone marrow stromal cells elicit tissue sparing after acute but not delayed transplantation into the contused adult rat thoracic spinal cord

RatSpinal cord injury

Extraction: mesh. Machine-extracted fields require source verification.

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