Diallyl sulfide treatment protects against acetaminophen-/carbon tetrachloride-induced acute liver injury by inhibiting oxidative stress, inflammation and apoptosis in mice.
MouseChemical/toxinOral administration100, 200 or 400 micromol/kgPretreatment, 1 h before acetaminophen or carbon tetrachloride injection
Model: Acute liver injury induced by intraperitoneal injection of acetaminophen or carbon tetrachloride, with serum and liver collected 24 h after exposure
Diallyl sulfide pretreatment lowered serum aminotransferase activities and histological injury after both acetaminophen and carbon tetrachloride, restored the antioxidant system (reduced malondialdehyde, higher reduced to oxidised glutathione ratio, higher superoxide dismutase and catalase activity…
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