THERAPY DOSSIER · th-a4792c322582

Compensatory direct current electrical stimulation with anodes at the injury site and cathodes rostral and caudal

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

4 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03237091 ↗Injury indicationNAcompleted

Enhancing corticospinal excitability to improve functional recovery (tDCS/tPCS in tetraplegia)

Spinal Cord Injuries · Tetraplegia

Enrolment: 19 · Results not recorded

NCT06710808 ↗Injury indicationNAcompleted

Virtual walking and transcranial direct current stimulation for chronic neuropathic pain due to SCI

Spinal Cord Injury · Chronic Neuropathic Pain

Enrolment: 4 · Results not recorded

NCT03954496 ↗Injury indicationNAterminated

Improving hand recovery with neuromodulation in tetraplegia (tDCS plus motor training)

Spinal Cord Injuries · Tetraplegia, Incomplete, Chronic

Enrolment: 6 · Results not recorded

NCT03237234 ↗Injury indicationNAcompleted

Enhancing corticospinal activation for improved walking function (tDCS plus motor skill training)

Spinal Cord Injuries

Enrolment: 25 · Results not recorded

NCT01874782 ↗PHASE2completed

Transcranial electrical stimulation for orthostatic instability in acute cervical spinal cord injury

Orthostatic Hypotension · Postural Hypotension

Enrolment: 4 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24110517 ↗2013Reported benefit

Compensation for injury potential by electrical stimulation after acute spinal cord injury in rat.

RatSpinal cord injuryUnspecifiedFemaleElectrodes with anodes at the site of injury and cathodes at the rostral and caudal sectionsStimulation intensity adjusted so that injury potential was…Immediately after injury

Model: Acute spinal cord injury with measurement of injury potential, the direct current potential difference between normal and injured cord segments

Injury potentials after electrical stimulation were higher than in unstimulated rats and much lower than the initial amplitude, and the stimulating voltage needed to keep the injury potential at 0 mV stayed constant, which the authors interpret as membrane repair during stimulation and as support f…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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