THERAPY DOSSIER · th-a334202de536

5 mm LigaSure vessel sealing, compared with rubber band ligature and silk ligature

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 10

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01858987 ↗NAcompleted

Stapler vs LigaSure for Transection of the Parenchyma in Elective Hepatic Resection (CRUNSH II)

Liver Resection

Enrolment: 138 · Results not recorded

NCT05080114 ↗NAcompleted

Multimodal Concept for Vaginal Cuff Closure in Total Laparoscopic Hysterectomy

Hysterectomy · Surgery · Laparoscopy

Enrolment: 148 · Results not recorded

NCT02538328 ↗NAcompleted

Comparison of Harmonic Scalpel and LigaSure Devices in Laparoscopic Morbid Obesity Surgery

Morbid Obesity

Enrolment: 90 · Results not recorded

NCT02613156 ↗Phase not recordedcompleted

Efficacy Analysis of Complete Laparoscopic Resection of Recurrent Hepatocellular Carcinoma

Recurrent Hepatocellular Carcinoma

Enrolment: 25 · Results not recorded

NCT07522983 ↗NAcompleted

Incidence of Recurrent Laryngeal Injury Using LigaSure in Total Thyroidectomy vs Conventional Knot Tying

Thyroidectomy

Enrolment: 120 · Results not recorded

NCT04139876 ↗NAunknown

LigaSure Hemorrhoidectomy Versus Open Hemorrhoidectomy: Long-term Effect on Hemorrhoidal Symptoms

Hemorrhoids

Enrolment: 70 · Results not recorded

NCT00487409 ↗NAcompleted

Randomized Trial Comparing Outcomes for LigaSure and Disposable Stapling Instruments for Laparoscopic Surgery

Colonic Diseases · Rectal Diseases

Enrolment: 100 · Results not recorded

NCT04108923 ↗NAunknown

Comparative Study Between LigaSure Versus Conventional Vessel Ligation in Thyroidectomy

Thyroid Diseases

Enrolment: 80 · Results not recorded

NCT02822820 ↗NAcompleted

Impact of Bipolar Energy Modalities on Peri-operative Outcome During Laparoscopic Staging of Gynecologic Cancers

Perioperative Period

Enrolment: 68 · Results not recorded

NCT01163565 ↗NAcompleted

Prospective Randomized Equivalence Trial to Evaluate the Safety of LigaSure in Thyroid Surgery

Multinodular Goitre · Grave's Disease · Thyroid Nodule

Enrolment: 96 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25699264 ↗2015Reported benefit

Comparison and efficacy of LigaSure and rubber band ligature in closing the inflamed cecal stump in a rat model of acute appendicitis.

RatOtherSprague-DawleyMalen = 8 rats per subgroup in the day 8 group; group A subgroup si…Intra-operative surgical application to the caecal stump and mesocaecum, leaving about 1 mm of distal stump unburiedAt caecal resection, 24 h after caecal ligation

Model: Caecal ligation with 3-0 silk about 5 mm proximal to the caecal tip to produce obstruction, inflammation and gangrenous change, with caecal resection 24 h later to mimic appendectomy

LigaSure matched silk and outperformed rubber band ligature: at day 8 grade 4 adhesion occurred in 12.5 per cent of LigaSure animals versus 50 per cent for silk and 75 per cent for rubber band (p = 0.024), and hydroxyproline was highest with LigaSure (155.6 plus or minus 35.4 versus 106.8 plus or m…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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