THERAPY DOSSIER · th-a302bf3d83e9

Implanted extradural spinal cord electrical stimulation (receiver-stimulators driven by encircling antennae)

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 10

8 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06533969 ↗Injury indicationNArecruiting

Assessment of Neural Signals for the Control of Assistive Devices

Spinal Cord Injury (SCI), Initial Encounter

Enrolment: 3 · Results not recorded

NCT06515223 ↗Injury indicationNArecruiting

Improving Pelvic Rehabilitation Using Epidural Stimulation After Spinal Cord Injury

Spinal Cord Injuries · Neuromodulation · Neurogenic Bladder · Neurogenic Bowel · Neurogenic Detrusor Overactivity

Enrolment: 20 · Results not recorded

NCT03924388 ↗Injury indicationNAunknown

The Effects of Spinal Cord Stimulation on Autonomic Function in People With Spinal Cord Injury

Spinal Cord Injuries · Autonomic Dysreflexia · Orthostatic Hypotension, Dysautonomic

Enrolment: 46 · Results not recorded

NCT05705453 ↗Injury indicationNArecruiting

Epidural Stimulation After Neurologic Damage: Long-Term Outcomes

SCI - Spinal Cord Injury

Enrolment: 50 · Results not recorded

NCT03945331 ↗Injury indicationNAterminated

Characterization of Transcutaneous and Epidural Spinal Stimulation for Enabling Motor Function in Humans With Motor Complete Paraplegia

Paraplegia, Spinal · Paraplegia, Complete · Paraplegia; Traumatic

Enrolment: 2 · Results not recorded

NCT06867809 ↗Injury indicationNArecruiting

Pilot Study to Evaluate the Safety and Tolerability of Spinal Cord Stimulation (SCS) and Paired Spine And Brain Stimulation For Movement Recovery After Spinal Cord Injury (SCI)

Spinal Cord Injury · Spinal Cord Injury Cervical

Enrolment: 20 · Results not recorded

NCT04237363 ↗Injury indicationNAcompleted

Recovery of Walking Without Epidural Spinal Cord Stimulation in Adults With Complete Spinal Cord Injury

Spinal Cord Injuries

Enrolment: 5 · Results not recorded

NCT07722130 ↗Injury indicationNArecruiting

An Exploratory Clinical Trial of Cervical Epidural Spinal Cord Stimulation for Respiratory Recovery in Patients With Cervical Spinal Cord Injury

Spinal Cord Injury Cervical · Respiratory Failure

Enrolment: 20 · Results not recorded

NCT04157400 ↗NAcompleted

Neuromodulation of Motor and Sensory Spinal Pathways in Subjects Undergoing Epidural Spinal Cord Stimulation

Chronic Pain

Enrolment: 5 · Results not recorded

NCT04598035 ↗Phase not recordedactive not recruiting

Epidural Spinal Cord Stimulation for Hypertension in Patients With Neuropathic Pain

Chronic Pain · Hypertension · Implanted Stimulation Electrodes

Enrolment: 72 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 2433780 ↗1987No effect reported

Chronic regenerative changes in the spinal cord after cord compression injury in rats.

RatSpinal cord injuryCompressionWistarfemalen = 20 adult female rats in totalExtradural electrodes placed proximal and distal to the injury site, with subcutaneous receiver-stimulatorsElectrodes implanted immediately following injury

Model: Extradural clip compression of the spinal cord at T6-7

All 20 animals showed complete absence of normal cord tissue at the injury site with frequent cystic cavitation, and extensive regenerative changes were present in every animal, but statistical analysis showed no significant difference between stimulated and control groups.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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