THERAPY DOSSIER · th-a2c3ce2b8afe

Normal saline resuscitation (haemodilution)

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Haemorrhage/shock
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06253585 ↗NAcompleted

Precision Resuscitation With Crystalloids in Sepsis (PRECISE)

Sepsis

Enrolment: 2012 · Results not recorded

NCT01774214 ↗NAcompleted

Rapid Paediatric Fluid Resuscitation: Two Provider-Endorsed Manual Fluid Resuscitation Techniques

Resuscitation · Shock · Fluid Therapy

Enrolment: 16 · Results not recorded

NCT03020407 ↗NAcompleted

Inferior Vena Cava Ultrasound-guided Fluid Management in Septic Shock Resuscitation

Septic Shock

Enrolment: 211 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 21696767 ↗2011No effect reported

Hemodilution is not critical in the pathogenesis of the acute coagulopathy of trauma.

RatHaemorrhage/shockUnspecifiedSprague-DawleyMale2x shed blood volume normal salineAfter shock

Model: Trauma and haemorrhagic shock followed by resuscitation

Haemodilution up to 50% had a trivial effect on coagulation after trauma and haemorrhagic shock in rats in the absence of hypothermia and acidosis.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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