THERAPY DOSSIER · th-9dbd0a715b53

Silver-kaolin (Argostop) applied as an aerosol spray

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Burn
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 3664317 ↗1987Mixed findings

Evaluation of topical therapy with silver-kaolin (Argostop) in an experimental model of burn wound sepsis.

RatBurnScaldInbred strain (not further specified)MaleTopical aerosol spray to the burn woundApplied after burn; also applied before bacterial inoculation in one arm and af…

Model: 20 per cent total body surface area full-thickness dorsal scald burn, with surface inoculation of 2.5 x 10^8 Pseudomonas aeruginosa to model burn wound sepsis

Healing rates and wound colonisation did not differ between silver-kaolin treated and untreated wounds. After inoculation, mortality was 100% untreated, 71% with silver-kaolin, 9% with 1 per cent silver sulphadiazine, 6% when silver-kaolin was applied before inoculation, and 50% with kaolin alone,…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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