THERAPY DOSSIER · th-9cd7653f7094

Astrocyte-derived exosomes carrying GJA1-20k (connexin 43 isoform)

Biologic · Astrocyte-derived exosomes carrying GJA1-20k (connexin-43 isoform); engineered extracellular vesicle.

Evidence & regulatory context

Mechanism: Astrocyte-derived exosomes carrying GJA1-20k (connexin-43 isoform); engineered extracellular vesicle.
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31826322 ↗2019Reported benefit

Astrocytes-derived exosomes induce neuronal recovery after traumatic brain injury via delivering gap junction alpha 1-20 k.

MixedTBIFluid percussionfemale (per MeSH)Exosome transfer, route not stated

Model: Hydraulic (fluid pressure) traumatic brain injury in rats, with air pressure injury of cultured neurons in vitro

Astrocyte-derived exosomes carrying GJA1-20k were taken up by neurons, lowered apoptosis and improved mitochondrial function, with reduced brain damage confirmed in a rat traumatic brain injury model.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.45. Machine-extracted fields require source verification.

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