Decreased Survival After Combining Thoracic Irradiation and an Anti-PD-1 Antibody Correlated With Increased T-cell Infiltration Into Cardiac and Lung Tissues.
MouseRadiationC57Bl/6n = Not stated per group; five mice were irradiated in parallel…Injection in 100 uL PBS; exact route not stated200 ug per injection in 100 uL PBS for the three pre-irradi…Pretreatment 4 days before, 2 days before and immediately before irradiation
Model: Full thoracic X-ray irradiation, single dose of 20 Gy at 170 cGy/min, with head, neck, abdomen and lower body shielded by a custom lead cylinder; control animals received 0 Gy
Adding anti-PD-1 antibody to thoracic irradiation reduced 21-day survival from 70 per cent to 36 per cent (p=0.0169) and significantly increased T cell infiltration into heart and lung tissue
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