THERAPY DOSSIER · th-9a8af1eced21

Transcorneal alternating current stimulation (tACS)

Device · Device (transcorneal electrical/alternating current stimulation); not a ChEMBL entity

Evidence & regulatory context

Mechanism: Device (transcorneal electrical/alternating current stimulation); not a ChEMBL entity
Target: Not recorded
Injury models: Crush
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02019927 ↗Injury indicationNAcompleted

Transcorneal Electrical Stimulation to Improve Visual Function After Ocular Trauma

NAION · Ocular Trauma

Enrolment: 97 · Results not recorded

NCT07548944 ↗Phase not recordedrecruiting

Short-term Effects of Transcorneal Electrical Stimulation in Retinitis Pigmentosa

Retinitis Pigmentosa

Enrolment: 30 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23500179 ↗2013Mixed findings

Transcorneal alternating current stimulation after severe axon damage in rats results in long-term silent survivor neurons.

RatCrushPeripheral-nerve crushMaleTranscorneal electrical stimulation under anaesthesiaFirst treatment immediately after the lesion

Model: Severe optic nerve crush

On day 28 after crush, tACS-treated rats showed 28.2 percent neuronal survival compared with 8.6 percent in sham operates, indicating long-term protection from delayed retrograde cell death. All crush animals nevertheless remained impaired in brightness discrimination regardless of treatment and th…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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